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Ke Dong

Title

Professor

Profile

Ke Dong received a B.S. and an M.S. majoring in Entomology from Zhejiang Agricultural and Forestry University and Zhejiang University in China, respectively. She then moved to the US and received her Ph.D. in Entomology from Cornell University in 1993. After a short stay at the University of Kentucky, first as a postdoctoral associate and then research assistant professor, she relocated to Michigan State University (MSU) in 1995. Currently, she is a Professor in the Department of Entomology and in the Genetics and Neuroscience programs at MSU. She has served on the editorial boards of Insect Biochemistry and Molecular Biology and Pesticide Biochemistry and Physiology since 2008.

Over the past two decades, her lab made significant contributions to the understanding of the molecular action of pyrethroid insecticides on sodium channels as well as the molecular mechanism of knockdown resistance (kdr) to pyrethroids. Her current research interests center on the molecular, neuronal and behavioral bases of insect responses (mainly resistance and repellency) to natural and synthetic neuroactive compounds including insecticides.

Email

dongk@msu.edu

 

Address

Giltner Hall
293 Farm Lane Room 438B
East Lansing, MI 48824
 

Area of Expertise

Insect ion channels and receptors

Mode of action of insecticides

Mechanisms of insecticide resistance

Insect repellency

 

Selected Publications

 

Wu S, Nomura Y, Du Y, Zhorov BS, Dong K (2017) Molecular basis of selective resistance of the bumblebee BiNav1 sodium channel to tau-fluvalinate. Proc Natl Acad Sci USA114:12922-12927. 

Du, Y., Nomura, Zhorov BS, and Dong. K. (2016) Evidence for dual receptor sites of DDT in the sodium channel. J. Biol. Chem.291:4638-48.

Du Y., Nomura Y., Satar G., Hu, Z., Nauen, R., He, S., Zhorov, B.S. and Dong K. (2013) Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. Proc. Natl. Acad. Sci. USA.110:11785-90.

Zhang T, Wang Z, Wang L, Luo N, Jiang L, Liu Z, Wu C-F, Dong K (2013) Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. PLoS Genetics9(3):e1003327.

Liu Z., Song W. and Dong K. (2004) Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. Proc. Natl. Acad. Sci. USA101:11862-11867. 

Zhou W., Chung I., Liu Z. Goldin A. L. and Dong K. (2004) A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron42: 101-112.