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Publication List


  1. Zhang J, Hao W, Zhorov BS, Dong K, Jiang D (2019) Discovery of a novel series of tricyclic oxadiazine 4a-Methyl esters based on indoxacarb as potential sodium channel blocker/modulator insecticides. J. Agric. Food Chem. 10.1021/acs.jafc.9b00826
  2. Chen M, Du Y, Wu S, Nomura Y, Zhu G, Zhorov BS, Dong K (2019) Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti. PLoS Neglected Tropical Diseases 13(6):e0007432.
  3. Du Y, Tikhonov DB, Nomura Y, Dong K, Zhorov BS (2018) Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels. Arch. Biochem. Biophys. 652:59-70.
  4. Ren M, Niu J, Hu B, Wei Q, Zheng C, Tian X, Gao C, He B, Dong K and Su J (2018) Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests. Insect  Biochem. Molec. Biol. 99:17-26.
  5. Chen M, Du Y, Zhu G, Takamatsu G, Ihara M, Matsuda K, Zhorov BS and Dong K (2018) Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes. Pest. Biochem. Physiol. 151:82-89.
  6. Chen X, Wang Y, Wu W, Dong K and Hu Z (2018) DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster. Pest. Biochem. Physiol. 148:190-198.
  7. Kirkpatrick DM, Leach HL, Xu P, Dong K, Isaacs R and Gut LJ (2018) Comparative Antennal and Behavioral Responses of Summer and Winter Morph Drosophila suzukii (Diptera: Drosophilidae) to Ecologically Relevant Volatiles. Environ. Entomol. 47:700-706.
  8. Dong K, Wu S, Nomura Y, Du Y and Zhorov B (2018) Mechanism of Selective Resistance of the Bumble Bee Sodium Channel BiNaV1 to TAU-Fluvalinate. Biophys. J. 114:633a.
  9. Satar G, Ulusoy MR, Nauen R and Dong K (2018) Neonicotinoid insecticide resistance among populations of Bemisia tabaci in the Mediterranean region of Turkey. B. Insectol. 71:171-177.
  10. S Wu, Y Nomura, Y Du, BS Zhorov, K Dong (2017) Molecular basis of selective resistance of the bumblebee BiNav1 sodium channel to tau-fluvalinate. Proc. Natl. Acad. Sci. 114:12922-12927.
  11. Silver K, Dong K and Zhorov BS (2017) Molecular Mechanism of Action and Selectivity of Sodium Channel Blocker Insecticides. Curr. Med. Chen. 24:2912-2924.
  12. Soderlund DM, Dong K and Salgado V (2017) Special Section On Ion Channels in Pain, Pleasure, Death and Disease: Electrophysiology in the Study of Drugs, Toxins, and Insecticides. Neurotoxicology 60:135-135.
  13. Chen M, Du Y, Nomura Y, Zhu G, Zhorov BS and Dong K (2017) Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids. Neurotoxicology 60:197-206.
  14. BS Zhorov, K Dong (2017) Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel. Neurotoxicology 60:171-177.
  15. Haddi K, Tomé HVV, Du Y, Valbon WR, Nomura Y, Martins GF, Dong K and Oliveira EE (2017) Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control. Sci. Rep. 7:46549.
  16. Chen M, Du Y, Nomura Y, Zhu G, Zhorov BS and Dong K (2017) Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance. Insect Biochem. Mol. Biol. 82:1-10.
  17. Du Y, Nomura Y, Zhorov BS and Dong K (2016) Sodium channel mutations and pyrethroid resistance in Aedes aegypti. Insects 7:E60.
  18. Zhang Y, Du Y, Jiang D, Behnke C, Nomura Y, Zhorov BS and Dong K (2016) The receptor site and mechanism of action of sodium channel blocker insecticides. J. Biol. Chem. 291:20113-20124.
  19. Du Y, Nomura Y, Zhorov BS and Dong K (2016) Evidence for dual binding sites for 1, 1, 1-trichloro-2, 2-bis (p-chlorophenyl) ethane (DDT) in insect sodium channels. J. Biol. Chem. 291:4638-4648.
  20. Hu Z, Du Y, Xiao X, Dong K and Wu W (2016) Insight into the Mode of Action of Haedoxan A from Phryma leptostachya. Toxins 8:53.
  21. Du Y, Zhang Y, Jiang D, Behnke C, Nomura Y, Dong K and Zhorov BS (2016) Mapping Receptor Sites for Sodium Channel Blocking Insecticides DCJW and Metaflumizone in an Insect Sodium Channel. Biophys. J. 110:112a. 
  22. Wang XL, Su W, Zhang JH, Yang YH, Dong K and Wu YD (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella. Insect Sci. 23:50-58.
  23. Jiang D, Du Y, Nomura Y, Wang X, Wu Y, Zhorov BS and Dong K (2015) Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics. Insect Biochem. Mol. Biol. 66:88-95.
  24. Bourdin CM, Guérineau NC, Murillo L, Quinchard S, Dong K and Legros C (2015) Molecular and functional characterization of a novel sodium channel TipE-like auxiliary subunit from the American cockroach Periplaneta americana. Insect Biochem. Mol. Biol. 66:136-144.
  25. Dong K, Du Y, Rinkevich F, Wang L and Xu P (2015) The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. Pest. Biochem. Physiol. 120:36-39.
  26. Wang L, Du Y, Nomura Y and Dong K (2015) Distinct modulating effects of TipE-homologs 2–4 on Drosophila sodium channel splice variants. Insect Biochem. Mol. Biol. 60:24-32.
  27. Rinkevich FD, Du Y, Tolinski J, Ueda A, Wu CF, Zhorov BS and Dong K (2015) Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. Neurotoxicology 47:99-106.
  28. Wang L, Nomura Y, Du Y, Liu N, Zhorov BS and Dong K (2015) A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance. Mol. Pharmacol. 87:421-429.
  29. Gurevitz M, Gordon D, Barzilai MG, Kahn R, Cohen L, Moran Y, Zilberberg N, Froy O, Altman-Gueta H, Turkov M, Dong K and Karbat I (2015) Molecular description of scorpion toxin interaction with voltage-gated sodium channels. In: Scorpions Venoms p. 471-491, Gopalakrishnakone P. (eds) Toxinology. Springer, Dordrecht.
  30. Dong K, Du Y, Rinkevich F, Nomura Y, Xu P, Wang L, Silver K and Zhorov BS (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Insect Biochem. Mol. Biol. 50:1-17.
  31. Gao R, Du Y, Wang L, Nomura Y, Satar G, Gordon D, Gurevitz M, Goldin AL and Dong K (2014) Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. Neuroscience 268:297-308.
  32. Silver KS, Du Y, Nomura Y, Oliveira EE, Salgado VL, Zhorov BS and Dong K (2014) Voltage-gated sodium channels as insecticide targets. Advances in Insect Physiology 46:389-433.
  33. Oliveira EE, Du Y, Nomura Y and Dong K (2013) A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides. Neurotoxicology 38:42-50.
  34. Bourdin CM, Moignot B, Wang L, Murillo L, Juchaux M, Quinchard S, Lapied B, Guérineau NC, Dong K and Legros C (2013) Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity. PloS one 8:e67290.
  35. Wang L, Nomura Y, Du Y and Dong K (2013) Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. PloS one 8:e67551.
  36. Du Y, Nomura Y, Satar G, Hu Z, Nauen R, He SY, Zhorov BS and Dong K (2013) Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. Proc. Natl. Acad. Sci. 110:11785-11790.
  37. Rinkevich FD, Du Y and Dong K (2013) Diversity and convergence of sodium channel mutations involved in resistance to pyrethroids. Pestic. Biochem. Physiol. 106:93-100.
  38. Zhang T, Wang Z, Wang L, Luo N, Jiang L, Liu Z, Wu CF and Dong K (2013) Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. PLoS Genetics 9:e1003327.
  39. Li T, Zhang L, Reid WR, Xu Q, Dong K and Liu N (2012) Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatusSci. Rep. 2:781.
  40. Xu Q, Zhang L, Li T, Zhang L, He L, Dong K and Liu N (2012) Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes. PloS one 7:e47609.
  41. Cui YJ, Yu LL, Xu HJ, Dong K and Zhang CX (2012) Molecular characterization of DSC1 orthologs in invertebrate species. Insect Biochem. Molec. Biol. 42:353-359.
  42. Du Y, Khambay B and Dong K (2011) An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. Insect Biochem. Molec. Biol. 41:446-450.
  43. Zhang T, Liu Z, Song W, Du Y and Dong K (2011) Molecular characterization and functional expression of the DSC1 channel. Insect Biochem. Molec. Biol. 41:451-458.
  44. Du Y, Garden DP, Khambay B, Zhorov B and Dong K (2011) Batrachotoxin, Pyrethroids and BTG 502 Share Overlapping Binding Sites On Insect Sodium Channels. Mol. Pharmacol. mol.111.072504.
  45. Song W, Du Y, Liu Z, Luo N, Turkov M, Gordon D, Gurevitz M, Goldin AL and Dong K (2011) Substitutions in the domain III voltage sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. J. Biol. Chem. jbc. M110. 217000.
  46. Du Y, Garden D, Wang L, Zhorov BS and Dong K (2011) Identification of new batrachotoxin-sensing residues in segment IIIS6 of sodium channel. J. Biol. Chem. jbc. M110. 208496.
  47. Parker L, Padilla M, Du Y, Dong K and Tanouye MA (2011) Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. Genetics 187:523-534.
  48. Song W, Silver KX, Du Y, Liu Z and Dong K (2011) Analysis of the action of lidocaine on insect sodium channels. Insect Biochem. Molec. Biol. 41:36-41.
  49. Hu Z, Y Du, Nomura Y and Dong K (2011) A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids. Insect Biochem. Molec. Biol. 41:9-13.
  50. Du Y, Song W, Groome JR, Nomura Y, Luo N and Dong K (2010) A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. Toxicol. Appl. Pharmacol. 247:53-59.
  51. Silver KS, Song W, Nomura Y, Salgado VL and Dong K (2010) Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels. Pestic. Biochem. Physiol. 97:87-92.
  52. Du Y, Nomura Y, Liu Z, Huang ZY and Dong K (2009) Functional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels. J. Biol. Chem. 284:33869-33875.
  53. Silver KS, Nomura Y, Salgado VL and Dong K (2009) Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides. Neurotoxicology 30:613-621.
  54. Du Y, Lee JE, Nomura Y, Zhang T, Zhorov BS and Dong K (2009) Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. Biochem. J. 419:377-385.
  55. Shao YM, Dong K, Tang ZH and Zhang CX (2009) Molecular characterization of a sodium channel gene from the Silkworm Bombyx mori. Insect Biochem. Molec. Biol. 39:145-151.
  56. Du Y, Nomura Y, Luo N, Liu Z, Lee JE, Khambay B and Dong K (2009) Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. Toxicol. Appl. Pharmacol.234:266-272.
  57. Olson ROD, Liu Z, Nomura Y, Song W and Dong K (2008) Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster. Insect Biochem. Molec. Biol. 38:604-610.
  58. Peterson RT, Nass R, Boyd WA, Freedman JH, Dong K and Narahashi T (2008) Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology 29:546-555.
  59. Hollingworth RM and Dong K (2008) The biochemical and molecular genetic basis of resistance to pesticides in arthropods. in: Global pesticide resistance in arthropods, 40-89.
  60. Shao YM, Dong K and Zhang CX (2007) The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx moriBMC genomics 8:324.
  61. Gordon D, Karbat I, Ilan N, Cohen L, Kahn R, Gilles N, Dong K, Stühmer W, Tytgat J and Gurevitz M (2007) The differential preference of scorpion α-toxins for insect or mammalian sodium channels: Implications for improved insect control. Toxicon. 49:452–472.
  62. Gurevitz M, Karbat I, Cohen L, Ilan N, Kahn R, Turkov M, Stankiewicz M, Stühmer W, Dong K and Gordon D (2007) The insecticidal potential of scorpion β-toxins. Toxicon 49:473-489.
  63. Dong K (2007) Insect sodium channels and insecticide resistance. Invert. Neurosci. 7:17-30.
  64. Liu Z, Tan J, Huang ZY and Dong K (2006) Effect of a fluvalinate-resistance-associated sodium channel mutation from varroa mites on cockroach sodium channel sensitivity to fluvalinate, a pyrethroid insecticide. Insect Biochem. Molec. Biol. 36:885-889.
  65. Song W, Liu Z and Dong K (2006) Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. Neurotoxicology 27:237-244.
  66. Du Y, Liu Z, Nomura Y, Khambay B and Dong K (2006) An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. Insect Biochem. Molec. Biol. 36:161-168.
  67. Tan J, Liu Z, Wang R, Huang ZY, Chen AC, Gurevitz M, and Dong K (2005) Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.  Mol. Pharmacol.  67:513-522.
  68. Liu Z, Song W and Dong K (2004) Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. Proc. Natl. Acad. Sci. 101:11862-11867.
  69. Song W, Liu Z, Tan J, Nomura Y and Dong K (2004) RNA editing generates tissue-specific sodium channels with distinct gating properties. J. Biol. Chem. 279:32554-32561.
  70. Zhou W, Chung I, Liu Z, Goldin AL and Dong K (2004) A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron 42:101-112.
  71. Wang R, Huang ZY and Dong K (2003) Molecular characterization of an arachnid sodium channel gene from the varroa mite (Varroa destructor). Insect Biochem. Molec. Biol. 33:733-739.
  72. Tan J, Liu Z, Nomura Y, Goldin AL and Dong K (2002) Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. J. Neurosci. 22:5300-5309.
  73. Liu Z, Tan J, Valles SM and Dong K (2002) Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide. Insect Biochem. Molec. Biol. 32:397-404.
  74. Tan J, Liu Z, Tsai T, Valles SM, Goldin AL and Dong K (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. Insect Biochem. Molec. Biol. 32:445-454.
  75. Wang R, Liu Z, Dong K, Elzen PJ, Pettis J and Huang Z (2002) Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Varroa destructor. J. Apic. Res. 41:17-25.
  76. Liu Z, Chung I and Dong K (2001) Alternative splicing of the BSC1 gene generates tissue-specific isoforms in the German cockroach. Insect Biochem. Molec. Biol. 31:703-713.
  77. Liu Z, Valles SM and Dong K (2000) Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides. Insect Biochem. Molec. Biol. 30:991-997.
  78. Valles SM, Dong K and Brenner RJ (2000) Mechanisms responsible for cypermethrin resistance in a strain of German cockroach, Blattella germanicaPestic. Biochem. Physiol. 66:195-205.
  79. Liu Z, Tan J, Dong K, Tsai TD, Valles SM and Goldin AL (2000) Knockdown resistance (kdr) to pyrethroid insecticides in the German cockroach. Resistant Pest Management 11:25p..
  80. Dong K, Valles SM, Scharf ME, Zeichner B and Bennett GW (1998) The knockdown resistance (kdr) mutation in pyrethroid-resistant German cockroaches. Pestic. Biochem. Physiol. 60:195-204.
  81. Dong K (1997) A single amino acid change in the Para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. Insect Biochem. Molec. Biol. 27:93-100.
  82. Scott JG and Dong K (1994) kdr-Type resistance in insects with special reference to the German cockroach, Blattella germanica. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 109:191-198.
  83. Dong K and Scott JG (1994) Linkage of the kdr-type resistance locus to the sodium channel gene in German cockroaches. Insect  Biochem. Molec. Biol. 24:647-654.
  84. Dong K, Scott JG and Weiland GA (1993) [3H]-Batrachotoxinin A-20-α-benzoate Binding in Synaptosomes from Susceptible and kdr-Type Resistant German Cockroaches, Blattella germanica (L.). Pestic. Biochem. Physiol. 46:141-148.
  85. Dong K and Scott JG (1992) Synergism of chlorpyrifos against the German cockroach, Blattella germanica. Med. Vet. Entomol. 6:241-243.
  86. Dong K and Scott JG (1991) Neuropharmacology and genetics of kdr-type resistance in the German cockroach, Blattella germanica (L.). Pestic. Biochem. Physiol.41:159-169.
  87. Scott JG, Dong K, Geden CJ and Rutz DA (1990) Evaluation of the biochemical basis of insecticide selectivity between host and parasitoid species. Environ.  Entomol. 19:1722-1725.