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Publications

  1. Dong, K., Du, Y., Rinkevich F., Wang, L., and Xu, P. (2015) The Drosophila sodium channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. Pestic. Biochem. Physiol. 120:36–9.
  2. Du, Y., Nomura, Y., Zhorov, BS., Dong, K. (2015) Rotational Symmetry of two pyrethroid receptor sites in the mosquito sodium channel. Mol. Pharmacol.  In press.
  3. Wang, L, Du, YZ, Nomura, Y and Dong K. (2015) Distinct modulatory effects of TipE homologs 2-4 on Drosophila sodium channel splice variants. Insect Biochem. Mol. Biol. 60:24-32.
  4. Rinkevich FD, Du, Y., Tolinski, J, Ueda, A. Wu, C-F, Zhorov, BS, Dong, K (2015) Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. Neurotoxicol. 47:99-106.
  5. Wang, L, Nomura Y., Du, Y., Liu N. Zhorov BS. and Dong K. (2015) A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance. Mol. Pharmacol. 106:93–100 (IF: 4.12).
  6. Gurevitz, M., Gordon, D., Gur Barzilai, M., Kahn, R., Cohen, L., Moran, Y., Zilberberg, N., Froy, O., Altman-Gueta, H., Turkov, M., Dong, K. and Karbat, K. (2014) Molecular description of scorpion toxin interaction with voltage-gated sodium channels. In Toxinology: Scorpion Venoms (Gopalakrishnakone, P., Schartz, E. F., Possani, L. D. and Rodriguez de la Vega, R. C., eds.) pp. 1-19, Springer, Dordrecht.
  7. Gao R, Du Y, Wang L, Nomura Y, Satar G, Gordon D, Gurevitz M, Goldin AL, and Dong K (2014) Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. Neurosci.  268C:297-308 (IF: 3.327).
  8. Dong K, Du Y, Rinkevich FD, Nomura Y, Xu P, Wang L, Silver K and Zhorov BS (2014) Molecular biology of insect sodium channels and pyrethroid resistance. Insect Biochem. Mol. Biol. 50:1-17(IF: 3.42).
  9. Silver K, Du Y, Nomura Y, Oliveira EE, Salgado V, Zhorov BS and Dong K. Voltage-gated sodium channels as insecticide targets. InTarget receptors in the control of insect pests.” Part II. Vol. 46, ed. Ephraim Cohen, AIIP, UK: Academic Press, 2014, pp.389-433.
  10. Rinkevich FD, Du Y and Dong K (2013) Diversity and convergence of sodium channel mutations involved in resistance to pyrethroids. Pestic. Biochem. Physiol. 106:93–100.
  11. Du Y., Nomura Y., Satar G., Hu, Z., Nauen, R., He, S., Zhorov, B.S. and Dong K. (2013) Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. Proc. Natl. Acad. Sci. USA. 110:11785-90.
  12. Wang L., Nomura V., Du Y., Dong K. (2013). Differential effects of TipE and a TipE-Homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. PLoS ONE 8(7): e67551.
  13. Yuzhe Du, Yoshiko Nomura, Gul Satar, Zhaonong Hu, Ralf Nauen, Sheng Yang He, Boris S. Zhorov, and Ke Dong (2013) Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. PNAS. In press.
  14. Eugênio E. Oliveira, Yuzhe Du, Yoshiko Nomura, Ke Dong (2013) A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides. Neurotox. In press.
  15. Céline M Bourdin, Bénédicte Moignot, Laurence Murillo, Marjorie Juchaux, Sophie Quinchard, Bruno Lapied, Nathalie C Guérineau, Lingxin Wang, Ke Dong and Christian Legros (2013) Intron retention in mRNA encoding auxiliary subunit of insect voltage-gated sodium channel as an unanticipated mechanism involved in channel expression, gating regulation and drug sensitivity.  PloS One. In press.
  16. Zhang, T., Wang, Z., Wang, L.,Luo N., Jiang, L., Liu, Z. Wu, C-F., Dong, Ke (2013) Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress. PLoS Genetics 9(3):e1003327.
  17. Cui, Y.J., Yu, L.L., Xu, H.J., Dong, K. and Zhang, C.X. (2012) Molecular characterization of DSC1 orthologs in invertebrate species. Insect Biochem. Mol. Biol. 42:353-9.
  18. Li T, Zhang L, Reid WR, Xu Q, Dong K, Liu N. (2012) Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus.  Sci Rep. 2 DOI 10.1038/srep00781.
  19. Xu Q, Zhang L, Li T, Zhang L, He L, Dong K, Liu N. (2012) Evolutionary Adaptation of the Amino Acid and Codon Usage of the Mosquito Sodium Channel following Insecticide Selection in the Field Mosquitoes. PLoS One  7 e47609.
  20. Du, Y. Garden, D. P., Khambay, B., Zhorov B. S., Dong, K. (2011) Batrachotoxin, pyrethroids and BTG 502 share overlapping binding sites on insect sodium channels. Mol. Pharmacol. 80: 426-433.
  21. Zhang, T., Liu, Z., Song, W., Du Y. Dong, K. (2011) Molecular characterization and functional expression of the DSC1 channel. Insect Biochem. Mol. Biol. 41:451-8.
  22. Song, W., Du, Y., Liu, Z., Luo, N., Turkov, M., Gordon, D., Gurevitz, M., Goldin, A. L., Dong, K. (2011) Substitutions in the domain III voltage sensor in domain enhance the sensitivity of an insect sodium channel to a scorpion β-toxin. J. Biol. Chem. 286:15781-8.
  23. Du, Y., Garden, D. P., Wang, L., Zhorov B. S., Dong, K. (2011a) Identification of new batrachotoxin-sensing residues in segment IIIS6 of sodium channel. J. Biol. Chem. 286:13151-60.
  24. Du, Y., Khambay, B., Dong, K. (2011b) An important role of a pyrethroid sensing residue F1519 in the action of an alkylamide insecticide BTG 502 on the cockroach sodium channel. Insect Biochem. Mol. Biol. 41:466-50.
  25. Parker, L., Padilla, M., Du, Y., Dong, K., Tanouye, M.A. (2011) Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the Para sodium channel gene that leads to seizures. Genetics.187: 523-534.
  26. Song, W., Sliver K. S., Du, Y., Liu, Z., Dong, K. (2011) Analysis of the action of lidocaine on insect sodium channels. Insect Biochem. Mol. Biol. 41: 36-41.
  27. Hu, Z., Du, Y., Nomura, Y., Dong, K. (2011) A Sodium channel mutation identified inAedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids. Insect Biochem. Mol. Biol. 41: 9-13.
  28. Dong (2010) Progress in insect sodium channel research. In: Gilbert LI andGill SS (Eds) Insect  Pharmacology, Channels, Receptors, Toxins and Enzymes. Academic Press, p25-27.
  29. Silver KS, Song, W, Nomura Y, Salgado V. Dong K (2010) Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels. Pestic. Biochem. Physiol. 97:87-92.
  30. Du Y, Song W, Groome JR, Nomura Y, Luo N, Dong K (2010). A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. Toxicol. Appl. Pharmacol. 244: 374-384.
  31. Du Y, Nomura Y, Liu Z, Huang ZY, Dong K. (2009a) Functional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels. J Biol. Chem. 284: 33869-75.
  32. Silver KS, Nomura Y, Salgado VL, Dong K. (2009) Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides. Neurotoxicol. 30:613-21.
  33. Du Y., Lee, JE., Nomura, Y., Zhang, T., Zhorov BS., Dong K. (2009b) Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. Biochem. J. 419:377-85
  34. Du Y., Nomura Y., Luo N., Liu Z., Lee J-E., Khambay B., and Dong K. (2009c) Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. Toxicol. Appl. Pharmacol. 234:266-72.

Selected Publications Before 2009

  1. Dong K. (2007) Insect sodium channels and insecticide resistance. Invert. Neurosci. 7: 17-30.
  2. Tan J, Liu Z, Wang R, Huang ZY, Chen AC, Gurevitz M, and Dong K. (2005) Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.  Mol Pharmacol.  67:513-522.
  3. Song W., Liu Z., Tan J., Nomura Y. and Dong K. (2004) RNA editing generates tissue-specific sodium channels with distinct gating properties. J. Biol. Chem. 279:32554-32561.
  4. Liu Z., Song W. and Dong K. (2004) Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. Proc. Natl. Acad. Sci. USA 101:11862-11867.
  5. Zhou W., Chung I., Liu Z. Goldin A. L. and Dong K. (2004) A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron 42: 101-112.
  6. Tan J., Liu Z., Tsai T., Valles S. M., Goldin A. L. and Dong K. (2002) Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. Insect Biochem. Molec. Biol. 32:445-454.
  7. Dong K. (1997). A single amino acid change in the Para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach.  Insect Biochem. Molec. Biol.  27, 93-100.
  8. Dong, K. and Scott, J. G. (1994).  Linkage of the kdr-type resistance locus to the sodium channel gene in German cockroaches.  Insect  Biochem. Molec. Biol. 24, 647-654.
  9. Dong K., Scott J. G. and Weiland G. A. (1993).  Binding of [3H]-batrachotoxinin A-20-a-benzoate to sodium channels in nerve membrane vesicles of susceptible and kdr-type resistant strains of German cockroaches, Blattella germanica  (L.). Pestic. Biochem. Physiol. 46, 141-148.