Our current research focuses on mode of action of insecticides; mechanisms of insecticide resistance; and the molecular biology, neurophysiology and neuropharmacology of two families of voltage-gated ion channels: 1) the Para family of voltage-gated sodium channels and 2) the DSC1 family of voltage-gated cation channels. While the Para family of voltage-gated sodium channels are well-known targets of insecticides, including pyrethroids, the DSC1 family of voltage-gated cation channels are potential targets of new insecticides.
Experimental models: Drosophila melanogaster; cockroaches, mosquitoes, mites and ticks.
Experimental approaches: molecular biology, electrophysiological analysis using Xenopus oocytes; Drosophila molecular genetics, neurophysiological and behavioral analysis.
- Lingxin Wang's College of Natural Science (CNS) summer dissertation completion fellowship
- Lingxin Wang's Driesbach Award for Outstanding Ph.D. student in the Department of Entomology
- Our recent publication in PNAS (Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel, Du et al., 2013) received a lot of media attention, including several news releases in local newspapers and TV news. For example: